Transcription & translation

  • state that a polypeptide is coded for by a gene and that a gene is a sequence of nucleotides that forms part of a DNA molecule
  • state that a gene mutation is a change in the sequence of nucleotides that may result in an altered polypeptide
  • describe the way in which the nucleotide sequence codes for the amino acid sequence in a polypeptide with reference to the nucleotide sequence for HbA (normal) and HbS (sickle cell) alleles of the gene for the β-globin polypeptide
  • describe how the information in DNA is used during transcription and translation to construct polypeptides, including the role of messenger RNA (mRNA), transfer RNA
    (tRNA) and the ribosomes