DNA replication

  • describe the semi-conservative replication of DNA during interphase
  • describe the process of semi-conservative replication of DNA in terms of:
    • unwinding of the double helix
    • breakage of hydrogen bonds between complementary bases in the polynucleotide strands
    • the role of DNA helicase in unwinding DNA and breaking its hydrogen bonds
    • attraction of new DNA nucleotides to exposed bases on template strands and base pairing
    • the role of DNA polymerase in the condensation reaction that joins adjacent nucleotides
  • evaluate the work of scientists in validating the Watson–Crick model of DNA replication